Testosterone differentially modulates gonadotropin subunit messenger ribonucleic acid responses to gonadotropin-releasing hormone pulse amplitude.

@article{IliffSizemore1990TestosteroneDM,
  title={Testosterone differentially modulates gonadotropin subunit messenger ribonucleic acid responses to gonadotropin-releasing hormone pulse amplitude.},
  author={S A Iliff-Sizemore and G A Ortolano and Daniel J. Haisenleder and Alan C. Dalkin and Kimberly A Krueger and John C. Marshall},
  journal={Endocrinology},
  year={1990},
  volume={127 6},
  pages={2876-83}
}
Testosterone (T) inhibits GnRH secretion and can also modulate the effects of GnRH on gonadotropin synthesis and secretion. To assess the effect of T on GnRH stimulation of alpha, LH beta, and FSH beta mRNA expression, we replaced T at three levels to reproduce low (1.5 +/- 0.5 ng/ml), medium (3.5 +/- 0.3 ng/ml), and high (6.2 +/- 0.6 ng/ml) physiological… CONTINUE READING