Testosterone depletion contributes to cyclosporine-induced chronic impairment of acetylcholine renovascular relaxations.

Abstract

The immunosuppressant drug cyclosporine causes nephrotoxicity mainly via alterations of renovascular reactivity. This study investigated whether this effect of cyclosporine is modulated by the male gonadal hormone testosterone. The endothelium-dependent and -independent relaxations evoked by acetylcholine and sodium nitroprusside, respectively, were… (More)

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@article{ElMas2003TestosteroneDC, title={Testosterone depletion contributes to cyclosporine-induced chronic impairment of acetylcholine renovascular relaxations.}, author={Mahmoud M. El-Mas and Elham A. Afify and Amal G. Omar and Mahmoud M. Mohy El-Din and Fouad M. Sharabi}, journal={European journal of pharmacology}, year={2003}, volume={468 3}, pages={217-24} }