• Corpus ID: 207876503

Testosterone deficiency syndrome — diagnosis and treatment — based on age-related testosterone referent levels

  title={Testosterone deficiency syndrome — diagnosis and treatment — based on age-related testosterone referent levels},
  author={Michał Rabijewski and Andrzej Gomuła},
Introduction. Androgen production decreases with men’s age, which is a result of the natural process of ageing. Total testosterone concentration decreases by average 1% a year. This process results in specific signs and symptoms, which are not only associated with the sexuality, but also negatively affect the bone mineral density and body content, increase the likelihood for metabolic syndrome, diabetes and cardiovascular disease. If low testosterone concentration is accompanied by hypogonadism… 
Late - Onset Hypogonadism - New Point of View
The paper presents the first attempt to establish international standards for testosterone serum concentration levels in different age groups and presents problems caused by testosterone deficiency and outlines the possibility of the treatment, which increases the induction of testosterone endosynthesis by hCG.
Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging
A positive relationship between the concentrations of Mg, Fe and Zn and endocrine system in aging men is indicated, in contrast to Mn and Cr.
The effect of bioactive components of plant origin on the physicochemical and sensory characteristics of functional sausages
Due to the natural aging process, the production of androgens decreases with age. The fall in testosterone production in men ranges from 1% to 2% per year (Feldman et al., 2002). This process affects


Androgen deficiency, diabetes, and the metabolic syndrome in men
  • R. Kalyani, A. Dobs
  • Medicine
    Current opinion in endocrinology, diabetes, and obesity
  • 2007
Testosterone supplementation, by either oral or intramuscular routes and through exogenous or endogenous delivery, has a promising role in this population although further clinical trials are needed.
Association of specific symptoms and metabolic risks with serum testosterone in older men.
In aging male patients, psychosomatic complaints and metabolic risk relate to testosterone in a symptom-specific manner, and there is no evidence that a uniform structure of testosterone concentrations and complaints exists within the cohort of elderly male patients.
Serum androgen levels in men: impact of health status and age.
In this cross-sectional study, serum androgens declined in aging men, and the extent of this decrease correlated with health status, and a fixed, non-age-adjusted reference value does not adequately reflect this and might lead to a false diagnosis of androgen deficiency, particularly in elderly men.
Effects of testosterone replacement in hypogonadal men.
It is concluded from this study that replacing testosterone in hypogonadal men increases bone mineral density of the spine and hip, fat-free mass, prostate volume, erythropoiesis, energy, and sexual function.
Effects of age on testicular function and consequences of testosterone treatment.
  • P. Snyder
  • Biology, Medicine
    The Journal of clinical endocrinology and metabolism
  • 2001
The findings that LH secretory burst amplitude decreases with increasing age and that this decrease was the most prominent determinant of decreased testosterone secretion indicates a degree of secondary hypogonadism is supported by the failure of LH secretion to respond to drug-induced reduction of the serum testosterone concentration in old men as well as in young men.
Endogenous sex hormones and metabolic syndrome in aging men.
Higher testosterone and SHBG levels in aging males are independently associated with a higher insulin sensitivity and a reduced risk of the metabolic syndrome, independent of insulin levels and body composition measurements, suggesting that these hormones may protect against the development of metabolic syndrome.
Improvement of sexual function in men with late-onset hypogonadism treated with testosterone only.
Restoring testosterone levels to normal in men with proven subnormal testosterone levels improves libido in most subjects, and erectile function in more than 50% of these men.
Androgen Deficiency in The Adult Male: Causes, Diagnosis and Treatment
This book presents a method for calculating a Nomogram for Calculating Free Testosterone using data from the International Society for the Study of the Aging Male and The Endocrine Society Testosterone pellet implantation studies.
Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging.
Observations of health factor independent, age-related longitudinal decreases in T and free T, resulting in a high frequency of hypogonadal values, suggest that further investigation of T replacement in aged men, perhaps targeted to those with the lowest serum T concentrations, are justified.
Prevalence and incidence of androgen deficiency in middle-aged and older men: estimates from the Massachusetts Male Aging Study.
  • Andre B Araujo, A. O'donnell, +4 authors J. Mckinlay
  • Medicine
    The Journal of clinical endocrinology and metabolism
  • 2004
Estimates of the crude and age-specific prevalence and incidence rates of androgen deficiency in a randomly sampled population-based cohort of middle-aged and older men and projections for the number of cases in the 40- to 69-yr-old U.S. male population were computed.