Testosterone decreases reactive astroglia and reactive microglia after brain injury in male rats: role of its metabolites, oestradiol and dihydrotestosterone.

@article{Barreto2007TestosteroneDR,
  title={Testosterone decreases reactive astroglia and reactive microglia after brain injury in male rats: role of its metabolites, oestradiol and dihydrotestosterone.},
  author={George Barreto and Sergio J Veiga and I{\~n}igo Azcoitia and Luis Miguel Garcia-Segura and Daniel Garcia-Ovejero},
  journal={The European journal of neuroscience},
  year={2007},
  volume={25 10},
  pages={3039-46}
}
Previous studies have shown that the neuroprotective hormone, testosterone, administered immediately after neural injury, reduces reactive astrogliosis. In this study we have assessed the effect of early and late therapy with testosterone or its metabolites, oestradiol and dihydrotestosterone, on reactive astroglia and reactive microglia after a stab wound brain injury in orchidectomized Wistar rats. Animals received daily s.c. injections of testosterone, oestradiol or dihydrotestosterone on… CONTINUE READING

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