Testosterone attenuates beta-amyloid toxicity in cultured hippocampal neurons.

@article{Pike2001TestosteroneAB,
  title={Testosterone attenuates beta-amyloid toxicity in cultured hippocampal neurons.},
  author={Christian J Pike},
  journal={Brain research},
  year={2001},
  volume={919 1},
  pages={160-5}
}
Accumulating evidence suggests that testosterone has neurotrophic and perhaps neuroprotective actions. Thus, age-related depletion of testosterone may increase the brain's vulnerability to Alzheimer's disease and related disorders. To begin investigating this issue, cultured neurons were exposed to the Alzheimer-related insult beta-amyloid in the presence of testosterone. beta-Amyloid neurotoxicity was significantly reduced by testosterone via a rapid, estrogen-independent mechanism. These data… CONTINUE READING
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