Testosterone attenuates beta-amyloid toxicity in cultured hippocampal neurons.

  title={Testosterone attenuates beta-amyloid toxicity in cultured hippocampal neurons.},
  author={Christian J Pike},
  journal={Brain research},
  volume={919 1},
Accumulating evidence suggests that testosterone has neurotrophic and perhaps neuroprotective actions. Thus, age-related depletion of testosterone may increase the brain's vulnerability to Alzheimer's disease and related disorders. To begin investigating this issue, cultured neurons were exposed to the Alzheimer-related insult beta-amyloid in the presence of testosterone. beta-Amyloid neurotoxicity was significantly reduced by testosterone via a rapid, estrogen-independent mechanism. These data… CONTINUE READING
60 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 60 extracted citations

Similar Papers

Loading similar papers…