Testosterone as a protective factor against atherosclerosis--immunomodulation and influence upon plaque development and stability.

@article{Malkin2003TestosteroneAA,
  title={Testosterone as a protective factor against atherosclerosis--immunomodulation and influence upon plaque development and stability.},
  author={Chris J. Malkin and Peter J. Pugh and Richard Dickey Jones and Thomas Hugh Jones and Kevin S. Channer},
  journal={The Journal of endocrinology},
  year={2003},
  volume={178 3},
  pages={373-80}
}
Inflammation plays a central pathogenic role in the initiation and progression of coronary atheroma and its clinical consequences. Cytokines are the mediators of cellular inflammation and promote local inflammation in the arterial wall, which may lead to vascular smooth muscle apoptosis, degradation of the fibrin cap and plaque rupture. Platelet adhesion and thrombus formation then occur, resulting clinically in unstable angina or myocardial infarction. Recent studies have suggested that… CONTINUE READING
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Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study

  • AE Hak, JC Witteman, FH de Jong, MI Geerlings, A Hofman, HA Pols
  • Journal of Clinical Endocrinology and Metabolism
  • 2002
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