Testosterone and trenbolone enanthate increase mature myostatin protein expression despite increasing skeletal muscle hypertrophy and satellite cell number in rodent muscle

@article{Dalbo2017TestosteroneAT,
  title={Testosterone and trenbolone enanthate increase mature myostatin protein expression despite increasing skeletal muscle hypertrophy and satellite cell number in rodent muscle},
  author={Vincent J Dalbo and Michael D. Roberts and C. Brooks Mobley and Christopher G. Ballmann and Wesley C. Kephart and Carlton D. Fox and Vincent Santucci and Christine F. Conover and Luke Allen Beggs and Alexander Balaez and Frederic J. Hoerr and Joshua F Yarrow and Stephen E. Borst and Darren T. Beck},
  journal={Andrologia},
  year={2017},
  volume={49}
}
Key MethodThe androgen-induced alterations in adult rodent skeletal muscle fibre cross-sectional area (fCSA), satellite cell content and myostatin (Mstn) were examined in 10-month-old Fisher 344 rats (n = 41) assigned to Sham surgery, orchiectomy (ORX), ORX + testosterone (TEST; 7.0 mg week-1 ) or ORX + trenbolone (TREN; 1.0 mg week-1 ). After 29 days, animals were euthanised and the levator ani/bulbocavernosus (LABC) muscle complex was harvested for analyses. LABC muscle fCSA was 102% and 94% higher in…Expand
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