Testosterone and farnesoid X receptor agonist INT-747 counteract high fat diet-induced bladder alterations in a rabbit model of metabolic syndrome

@article{Morelli2012TestosteroneAF,
  title={Testosterone and farnesoid X receptor agonist INT-747 counteract high fat diet-induced bladder alterations in a rabbit model of metabolic syndrome},
  author={Annamaria Morelli and Paolo Comeglio and S. Filippi and Erica Sarchielli and Ilaria Cellai and Linda 4 Vignozzi and Ravit Yehiely-Cohen and Elena Maneschi and Mauro Gacci and Marco Carini and L. Adorini and Gabriella Barbara Vannelli and Mario Maggi},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2012},
  volume={132},
  pages={80-92}
}
In the male, metabolic syndrome (MetS) is associated to an increased risk of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). A recently established rabbit model of high fat diet (HFD)-induced MetS showed hypogonadism and the presence of prostate gland alterations, including inflammation, hypoxia and fibrosis. The present study investigated whether HFD-induced MetS might also alter bladder structure and function. Testosterone and the farnesoid X receptor (FXR) agonist… CONTINUE READING

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