Testosterone administration to older men improves muscle function: molecular and physiological mechanisms.

@article{Ferrando2002TestosteroneAT,
  title={Testosterone administration to older men improves muscle function: molecular and physiological mechanisms.},
  author={Arny A. Ferrando and Melinda Sheffield-Moore and Catherine Weikart Yeckel and Charles R. Gilkison and Jie Jiang and Alison Achacosa and Steven A. Lieberman and Kevin D Tipton and Robert R. Wolfe and Randall J. Urban},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2002},
  volume={282 3},
  pages={
          E601-7
        }
}
We investigated the effects of 6 mo of near-physiological testosterone administration to older men on skeletal muscle function and muscle protein metabolism. Twelve older men (> or =60 yr) with serum total testosterone concentrations <17 nmol/l (480 ng/dl) were randomly assigned in double-blind manner to receive either placebo (n = 5) or testosterone enanthate (TE; n = 7) injections. Weekly intramuscular injections were given for the 1st mo to establish increased blood testosterone… 
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  • Medicine, Biology
    The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2011
TLDR
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TLDR
T replacement effects were fiber-type dependent, restricted to increases in cell size, P0, and peak power, and dependent on the paradigm selected (WK vs MO).
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TLDR
The results suggest that testosterone mitigates sarcopenia by improving muscle tissue to maintain a state of normality in aging men.
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TLDR
In this population of older men with limitations in mobility and a high prevalence of chronic disease, the application of a testosterone gel was associated with an increased risk of cardiovascular adverse events.
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TLDR
Treatment with a potent anabolic androgen may produce significant increases in muscle mass and strength after only 6 weeks in healthy older men, however, such treatment did not improve leg muscle power or walking speed.
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