Testosterone Rapidly Increases Neural Reactivity to Threat in Healthy Men: A Novel Two-Step Pharmacological Challenge Paradigm

  title={Testosterone Rapidly Increases Neural Reactivity to Threat in Healthy Men: A Novel Two-Step Pharmacological Challenge Paradigm},
  author={S. M. Goetz and L. Tang and M. Thomason and M. Diamond and J. Carr{\'e}},
  journal={Biological Psychiatry},
  • S. M. Goetz, L. Tang, +2 authors J. Carré
  • Published 2014
  • Psychology, Medicine
  • Biological Psychiatry
  • BACKGROUND Previous research suggests that testosterone (T) plays a key role in shaping competitive and aggressive behavior in humans, possibly by modulating threat-related neural circuitry. However, this research has been limited by the use of T augmentation that fails to account for baseline differences and has been conducted exclusively in women. Thus, the extent to which normal physiologic concentrations of T affect threat-related brain function in men remains unknown. METHODS In the… CONTINUE READING
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