Testosterone Deficiency Causes Endothelial Dysfunction via Elevation of Asymmetric Dimethylarginine and Oxidative Stress in Castrated Rats.

@article{Kataoka2017TestosteroneDC,
  title={Testosterone Deficiency Causes Endothelial Dysfunction via Elevation of Asymmetric Dimethylarginine and Oxidative Stress in Castrated Rats.},
  author={Tomoya Kataoka and Yuji Hotta and Yasuhiro Maeda and Kazunori Kimura},
  journal={The journal of sexual medicine},
  year={2017},
  volume={14 12},
  pages={
          1540-1548
        }
}
BACKGROUND Testosterone is believed to mediate the penile erectile response by producing adequate nitric oxide; therefore, testosterone deficiency results in erectile dysfunction through decreased nitric oxide bioavailability. However, the mechanisms underlying endothelial dysfunction in testosterone deficiency remain unclear. AIM To investigate the mechanism of endothelial dysfunction in a rat model of testosterone deficiency. METHODS Rats were distributed into 3 groups: castrated (Cast… CONTINUE READING