Testosterone, dehydroepiandrosterone, and physical performance in older men: results from the Massachusetts Male Aging Study.

@article{Odonnell2006TestosteroneDA,
  title={Testosterone, dehydroepiandrosterone, and physical performance in older men: results from the Massachusetts Male Aging Study.},
  author={Amy B O'donnell and Thomas G Travison and Susan S. Harris and Joyce L Tenover and John B. Mckinlay},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2006},
  volume={91 2},
  pages={
          425-31
        }
}
OBJECTIVE This manuscript examines the relationships of total testosterone (T), bioavailable T, dehydroepiandrosterone (DHEA), and DHEA sulfate (DHEAS) to measures of physical performance in a large, population-based, random sample of men. METHODS In the most recent wave of the Massachusetts Male Aging Study, measures of strength and physical performance [seven-item physical performance test (PPT), timed chair stand test, and grip strength] were made in 684 men, aged 55-85 yr. Complete… Expand
Endocrinology of Aging From a Muscle Function Point of View: Results From the Toledo Study for Healthy Aging.
TLDR
The main role that muscle function plays in the relationship between the hormonal status and hospitalization and mortality risk is demonstrated and could be taken into consideration as a way to classify patients for hormonal therapy. Expand
Precipitous Dehydroepiandrosterone Declines Reflect Decreased Physical Vitality and Function
  • D. Rendina, C. Ryff, C. Coe
  • Medicine
  • The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2017
TLDR
DHEA-S and DHEA below age-expected levels were associated with more chronic illness conditions and self-reported persistent pain and pain sensitivity upon manual palpation, suggesting a more precipitous decline is already indicative of reduced vigor and physical strength by middle age. Expand
Effects of dehydroepiandrosterone and atamestane supplementation on frailty in elderly men.
TLDR
The results of this double-blind, randomized trial do not support the hypothesis that hormone replacement with DHEA and/or atamestane might improve the course of frailty. Expand
Anabolic applications of androgens for functional limitations associated with aging and chronic illness.
TLDR
Testosterone replacement increases vertebral bone mineral density in young hypogonadal men and older men with low testosterone levels, but it is not known whether testosterone reduces fracture risk. Expand
Testosterone, frailty and physical function in older men
TLDR
Evidence on the T effect on muscle strength is conflicting and the effect on physical function is weak, and T treatment may provide modest improvements in lean mass among both frail and non-frail older men. Expand
Effects of Sex Steroid Hormones on Muscle Structure and Function – Clinical and Therapeutic Implications
The life expectancy of populations in the USA and Western European countries is increasing, but the prevalence of features of ageing, such as physical frailty and disability, increases in parallel,Expand
Dehydroepiandrosterone sulfate and fall risk in older people: Sex differences in the Pro.V.A. longitudinal study.
TLDR
Higher levels of DHEA-S are associated with a lower risk of falls and recurrent falls in older people, especially women. Expand
THE EFFECTS OF TREATMENT WITH PRASTERONE ( DHEA ) ON cIRcULAtING HoRMoNes , BoDY coMPosItIoN AND MUscLe stReNGtH IN MeN AND WoMeN
Nowadays many individuals are using “performance-enhancing” nutritional supplements. Many professional and nonprofessional athletes take the popular supplements, containing the hormone DHEAExpand
Free testosterone levels are associated with mobility limitation and physical performance in community-dwelling men: the Framingham Offspring Study.
TLDR
Lower levels of baseline FT are associated with a greater risk of incident or worsening mobility limitation in community-dwelling older men and whether this risk can be reduced with testosterone therapy needs to be determined by randomized trials. Expand
Are declining testosterone levels a major risk factor for ill-health in aging men?
  • B. Yeap
  • Medicine
  • International Journal of Impotence Research
  • 2009
TLDR
Testosterone therapy should be considered in hypogonadal men who meet rigorous criteria for the diagnosis of androgen deficiency, and randomized controlled trials of testosterone therapy are needed to clarify its role in the maintenance of general and sexual health in aging men. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 40 REFERENCES
Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle.
TLDR
Older men are as responsive as young men to testosterone's anabolic effects; however, older men have lower testosterone clearance rates, higher increments in hemoglobin, and a higher frequency of adverse effects. Expand
Lack of effect of dehydroepiandrosterone in obese men.
TLDR
It is suggested that, at a daily dose of 13.4-19.7 mg/kg, short-term DHEA administration does not affect the total weight, body fat mass, fat distribution, insulin sensitivity, or lipid status of obese young men. Expand
Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial.
TLDR
Testosterone supplementation improved strength, increased hemoglobin, and lowered leptin levels in older hypogonadal men in this patient population, and may have a role in the treatment of frailty in males with Hypogonadism. Expand
The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men.
TLDR
Those given testosterone had greater increases than those given placebo in muscle size in their arms and the strength of the arms and legs was assessed by bench-press and squatting exercises, respectively. Expand
Effect of oral DHEA on serum testosterone and adaptations to resistance training in young men.
TLDR
DHEA ingestion does not enhance serum testosterone concentrations or adaptations associated with resistance training in young men, and serum androstenedione concentrations increased significantly and similarly in the men treated with placebo and DHEA. Expand
Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T.
TLDR
It is demonstrated that T therapy in older men with low serum T improves physical performance and strength over 36 months, when administered alone or when combined with F, and suggested that high serum levels of dihydrotestosterone are not essential for these beneficial effects of T in men. Expand
Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men.
TLDR
It is suggested that in normal men DHEA administration reduces body fat, increases muscle mass, and reduces serum low density lipoprotein cholesterol levels. Expand
Effects of a two-week physiological dehydroepiandrosterone substitution on cognitive performance and well-being in healthy elderly women and men.
TLDR
The present data do not support the idea of strong beneficial effects of a physiological DHEA substitution on well-being or cognitive performance in healthy elderly individuals. Expand
Failure of dehydroepiandrosterone to influence energy and protein metabolism in humans.
TLDR
DHEA treatment caused a 9-fold increase in mean plasma DHEA sulfate concentrations, but had no significant effect on body weight or on two indices of lean body mass (total body water and total body potassium). Expand
Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age.
TLDR
It is concluded that increasing the serum testosterone concentrations of normal men over 65 yr of age to the midnormal range for young men decreased fat mass, principally in the arms and legs, and increased lean mass, chiefly in the trunk, but did not increase the strength of knee extension and flexion, as measured by dynamometer. Expand
...
1
2
3
4
...