Testosterone, Sex Hormone-Binding Globulin and the Metabolic Syndrome in Men: An Individual Participant Data Meta-Analysis of Observational Studies

Abstract

BACKGROUND Low total testosterone (TT) and sex hormone-binding globulin (SHBG) concentrations have been associated with the metabolic syndrome (MetS) in men, but the reported strength of association varies considerably. OBJECTIVES We aimed to investigate whether associations differ across specific subgroups (according to age and body mass index (BMI)) and… (More)
DOI: 10.1371/journal.pone.0100409

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