Testis-specific sulfoglycolipid, seminolipid, is essential for germ cell function in spermatogenesis.

@article{Zhang2005TestisspecificSS,
  title={Testis-specific sulfoglycolipid, seminolipid, is essential for germ cell function in spermatogenesis.},
  author={Yanlong Zhang and Yoshihiro Hayashi and Xinyao Cheng and Tae Watanabe and Xiangchun Wang and Naoyuki Taniguchi and Koichi Honke},
  journal={Glycobiology},
  year={2005},
  volume={15 6},
  pages={649-54}
}
More than 90% of the glycolipid in mammalian testis consists of a unique sulfated glyceroglycolipid, seminolipid. The sulfation of the molecule is catalyzed by a Golgi membrane-associated sulfotransferase, cerebroside sulfotransferase (CST). Disruption of the Cst gene in mice results in male infertility due to the arrest of spermatogenesis prior to the metaphase of the first meiosis. However, the issue of which side of the cell function-germ cells or Sertoli cells-is deteriorated in this mutant… CONTINUE READING
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