Testis-specific histone variants H2AL1/2 rapidly disappear from paternal heterochromatin after fertilization.

@article{Wu2008TestisspecificHV,
  title={Testis-specific histone variants H2AL1/2 rapidly disappear from paternal heterochromatin after fertilization.},
  author={Fang Jie Wu and C{\'e}cile Caron and Christine De Robertis and Saadi Khochbin and Sophie Rousseaux},
  journal={The Journal of reproduction and development},
  year={2008},
  volume={54 6},
  pages={413-7}
}
Before fertilization, the genome packaging of male and female gametes is very different. Indeed, whereas the female haploid genome is associated with histones in a somatic-like chromatin structure, most of the male genome is tightly bound to protamines. However, it has recently been demonstrated that the pericentric heterochromatin regions of the male genome are associated with specific H2A-like histone variants, named H2AL1 and H2AL2, suggesting a heterogeneous organization. The fate and role… CONTINUE READING

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