Testis-specific expression of a functional retroposon encoding glucose-6-phosphate dehydrogenase in the mouse.

@article{Hendriksen1997TestisspecificEO,
  title={Testis-specific expression of a functional retroposon encoding glucose-6-phosphate dehydrogenase in the mouse.},
  author={Peter J. M. Hendriksen and Jos W. Hoogerbrugge and Willy M. Baarends and Paulo de Boer and Jan Th. M. Vreeburg and Eduard A. Vos and Tette van der Lende and J. Anton Grootegoed},
  journal={Genomics},
  year={1997},
  volume={41 3},
  pages={
          350-9
        }
}
The X-chromosomal gene glucose-6-phosphate dehydrogenase (G6pd) is known to be expressed in most cell types of mammalian species. In the mouse, we have detected a novel gene, designated G6pd-2, encoding a G6PD isoenzyme. G6pd-2 does not contain introns and appears to represent a retroposed gene. This gene is uniquely transcribed in postmeiotic spermatogenic cells in which the X-encoded G6pd gene is not transcribed. Expression of the G6pd-2 sequence in a bacterial system showed that the encoded… CONTINUE READING
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