Testis‐specific protein, Y‐linked 1 activates PI3K/AKT and RAS signaling pathways through suppressing IGFBP3 expression during tumor progression

@article{Tu2019TestisspecificPY,
  title={Testis‐specific protein, Y‐linked 1 activates PI3K/AKT and RAS signaling pathways through suppressing IGFBP3 expression during tumor progression},
  author={Wenling Tu and Bo Yang and Xiangyou Leng and Xue Pei and Jinyan Xu and Mohan Liu and Qiang Dong and Da-chang Tao and Yongjie Lu and Yunqiang Liu and Yuan Yang},
  journal={Cancer Science},
  year={2019},
  volume={110},
  pages={1573 - 1586}
}
The testis‐specific protein, Y‐linked 1 (TSPY1), a newly recognized cancer/testis antigen, has been suggested to accelerate tumor progression. However, the mechanisms underlying TSPY1 cancer‐related function remain limited. By mining the RNA sequencing data of lung and liver tumors from The Cancer Genome Atlas, we found frequent ectopic expression of TSPY1 in lung adenocarcinoma (LUAD) and liver hepatocellular carcinoma (LIHC), and the male‐specific protein was associated with higher mortality… 
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TLDR
A large-scale deletion in the Yp11.2 region in a Chinese population based on the analysis of 34 selected Y-specific sequence-tagged sites indicated that the deleted region included part or all of the following five genes: PCDH11Y, TSPY, AMELY, TBL1Y, and RKY.
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References

SHOWING 1-10 OF 60 REFERENCES
The human Y‐encoded testis‐specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein
TLDR
The results suggest that TSPY could exert its oncogenic function(s) by interacting with eEF1As and stimulating gene expression via its enhancements in protein synthesis and gene transcription.
TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells
TLDR
It is suggested that TSPY expression increases cell proliferation in vitro and tumorigenesis in vivo, and microarray analysis demonstrates that numerous genes involved in the cell cycle and apoptosis are affected by TSPy expression in the HeLa cells.
Insulin-like growth factor binding protein-3 (IGFBP-3) acts as an invasion-metastasis suppressor in ovarian endometrioid carcinoma
TLDR
It is indicated that IGFBP-3 plays an important role as an invasion-metastasis suppressor in ovarian EC and in 35 patients with EC tumors, low IGF BP-3 expression correlated clinically with higher tumor grade, advanced stage and poor survival.
Male Germ Cell-Specific RNA Binding Protein RBMY: A New Oncogene Explaining Male Predominance in Liver Cancer
TLDR
Findings suggest that Y chromosome-specific RBMY is likely involved in the regulation of androgen receptor activity and contributes to male predominance of HCC.
Expression of the Y-Encoded TSPY is Associated with Progression of Prostate Cancer
TLDR
Observations suggest that expressions of TSPY and its binding partner EEF1A are associated with the development and progression of prostate cancer.
The Y‐located proto‐oncogene TSPY exacerbates and its X‐homologue TSPX inhibits transactivation functions of androgen receptor and its constitutively active variants
Abstract The gonadoblastoma gene, testis‐specific protein Y‐encoded (TSPY), on the Y chromosome and its X‐homologue, TSPX, are cell cycle regulators and function as a proto‐oncogene and a tumor
TSPY1 suppresses USP7-mediated p53 function and promotes spermatogonial proliferation
TLDR
It is found that TSPY1 could promote spermatogonial proliferation by decreasing the Usp7-modulated p53 level and influence the activity of p53 target molecules to expedite the G2/M phase transition and decrease cell apoptosis, accelerating cell proliferation.
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