Testing the silence of mutations: Transcriptomic and behavioral studies of GABA(A) receptor α1 and α2 subunit knock-in mice.

@article{Harris2011TestingTS,
  title={Testing the silence of mutations: Transcriptomic and behavioral studies of GABA(A) receptor α1 and α2 subunit knock-in mice.},
  author={R. Adron Harris and Elizabeth A Osterndorff-Kahanek and Igor Ponomarev and Gregg E Homanics and Yuri A. Blednov},
  journal={Neuroscience letters},
  year={2011},
  volume={488 1},
  pages={31-5}
}
Knock-in mice were constructed with mutations in the α1 (H(270), A(277)) and α2 (H(270), A(277)) subunits of the GABAA receptor, which resulted in receptors that lacked modulation by ethanol but retained normal responses to GABA in vitro. A key question is whether these mutant receptors also function normally in vivo. Perturbation of brain function was evaluated by gene expression profiling in the cerebral cortex and by behavioral pharmacology experiments with GABAergic drugs. Analysis of… CONTINUE READING