Testing the role of myeloid cell glucose flux in inflammation and atherosclerosis.

  title={Testing the role of myeloid cell glucose flux in inflammation and atherosclerosis.},
  author={Tomohiro Nishizawa and Jenny E Kanter and Farah Kramer and Shelley Barnhart and Xia Shen and Anuradha Vivekanandan-Giri and Valerie Z. Wall and Jason Kowitz and Sridevi Devaraj and Kevin D O'brien and Subramaniam Pennathur and Jingjing Tang and Robert S. Miyaoka and Elaine W. Raines and Karin E Bornfeldt},
  journal={Cell reports},
  volume={7 2},
Inflammatory activation of myeloid cells is accompanied by increased glycolysis, which is required for the surge in cytokine production. Although in vitro studies suggest that increased macrophage glucose metabolism is sufficient for cytokine induction, the proinflammatory effects of increased myeloid cell glucose flux in vivo and the impact on atherosclerosis, a major complication of diabetes, are unknown. We therefore tested the hypothesis that increased glucose uptake in myeloid cells… CONTINUE READING
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