Testing the role of apoA-I, HDL, and cholesterol efflux in the atheroprotective action of low-level apoE expression.

@article{Thorngate2003TestingTR,
  title={Testing the role of apoA-I, HDL, and cholesterol efflux in the atheroprotective action of low-level apoE expression.},
  author={Fayanne E. Thorngate and Patricia G. Yancey and Ginny Kellner-Weibel and Lawrence Lee Rudel and George H. Rothblat and David L Williams},
  journal={Journal of lipid research},
  year={2003},
  volume={44 12},
  pages={2331-8}
}
Low levels of transgenic mouse apolipoprotein E (apoE) suppress atherosclerosis in apoE knockout (apoE-/-) mice without normalizing plasma cholesterol. To test whether this is due to facilitation of cholesterol efflux from the vessel wall, we produced apoA-I-/-/apoE-/- mice with or without the transgene. Even without apoA-I and HDL, apoA-I-/-/apoE-/- mice… CONTINUE READING