Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice.

@article{Chen2011TestingTR,
  title={Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice.},
  author={Y Chen and Felix Scheuplein and John P Driver and Amanda A. Hewes and Peter C. Reifsnyder and Edward H. Leiter and David V Serreze},
  journal={Journal of immunology},
  year={2011},
  volume={186 7},
  pages={4278-84}
}
Although P2rx7 has been proposed as a type 1 diabetes (T1D) susceptibility gene in NOD mice, its potential pathogenic role has not been directly determined. To test this possibility, we generated a new NOD stock deficient in P2X(7) receptors. T1D development was not altered by P2X(7) ablation. Previous studies found CD38 knockout (KO) NOD mice developed accelerated T1D partly because of a loss of CD4(+) invariant NKT (iNKT) cells and Foxp3(+) regulatory T cells (Tregs). These immunoregulatory T… CONTINUE READING

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