Testing the key assumption of heritability estimates based on genome-wide genetic relatedness

Abstract

Comparing genetic and phenotypic similarity among unrelated individuals seems a promising way to quantify the genetic component of traits while avoiding the problematic assumptions plaguing twin- and other kin-based estimates of heritability. One approach uses a Genetic Relatedness Estimation through Maximum Likelihood (GREML) model for individuals who are… (More)
DOI: 10.1038/jhg.2014.33

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