Testing the importance of p27 degradation by the SCFskp2 pathway in murine models of lung and colon cancer.

@article{Timmerbeul2006TestingTI,
  title={Testing the importance of p27 degradation by the SCFskp2 pathway in murine models of lung and colon cancer.},
  author={Inke Timmerbeul and Carrie M Garrett-Engele and Uta Kossatz and Xueyan Chen and Eduardo J. Firpo and Viktor Gr{\"u}nwald and Kenji Kamino and Ludwig Wilkens and Ulrich Lehmann and Jan Buer and Robert Geffers and Stefan Kubicka and Michael P. Manns and Peggy L. Porter and James M Roberts and Nisar Peter Malek},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 38},
  pages={
          14009-14
        }
}
Decreased expression of the CDK inhibitor p27kip1 in human tumors directly correlates with increased resistance to chemotherapies, increased rates of metastasis, and an overall increased rate of patient mortality. It is thought that decreased p27 expression in tumors is caused by increased proteasomal turnover, in particular activation of the pathway governed by the SCFskp2 E3 ubiquitin protein ligase. We have directly tested the importance of the SCFskp-mediated degradation of p27 in… CONTINUE READING

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