Testing the genomic enrichment of a large copy number variation within schizophrenia linkage regions

@article{Freudenberg2012TestingTG,
  title={Testing the genomic enrichment of a large copy number variation within schizophrenia linkage regions},
  author={J. Freudenberg and Y. Freudenberg-Hua},
  journal={Psychiatric Genetics},
  year={2012},
  volume={22},
  pages={294–297}
}
We hypothesize that copy number variants (CNVs) contribute to the location of schizophrenia linkage regions. Therefore, we test whether CNVs published by the International Schizophrenia Consortium are enriched in schizophrenia linkage regions recorded in the Online Mendelian Inheritance in Man database. For each region, the number of overlapping CNV events and the number of CNV base pairs are compared with 10 000 random regions of matched size. This shows an enrichment of CNV events within the… Expand

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