Testing the causality between CYP9M10 and pyrethroid resistance using the TALEN and CRISPR/Cas9 technologies.

@article{Itokawa2016TestingTC,
  title={Testing the causality between CYP9M10 and pyrethroid resistance using the TALEN and CRISPR/Cas9 technologies.},
  author={Kentaro Itokawa and Osamu Komagata and Shinji Kasai and Kohei Ogawa and Takashi Tomita},
  journal={Scientific reports},
  year={2016},
  volume={6},
  pages={24652}
}
Recently-emerging genome editing technologies have enabled targeted gene knockout experiments even in non-model insect species. For studies on insecticide resistance, genome editing technologies offer some advantages over the conventional reverse genetic technique, RNA interference, for testing causal relationships between genes of detoxifying enzymes and resistance phenotypes. There were relatively abundant evidences indicating that the overexpression of a cytochrome P450 gene CYP9M10 confers… CONTINUE READING

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There were relatively abundant evidences indicating that the overexpression of a cytochrome P450 gene CYP9M10 confers strong pyrethroid resistance in larvae of the southern house mosquito Culex quinquefasciatus .
For studies on insecticide resistance , genome editing technologies offer some advantages over the conventional reverse genetic technique , RNA interference , for testing causal relationships between genes of detoxifying enzymes and resistance phenotypes .
There were relatively abundant evidences indicating that the overexpression of a cytochrome P450 gene CYP9M10 confers strong pyrethroid resistance in larvae of the southern house mosquito Culex quinquefasciatus .
For studies on insecticide resistance , genome editing technologies offer some advantages over the conventional reverse genetic technique , RNA interference , for testing causal relationships between genes of detoxifying enzymes and resistance phenotypes .
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