Testing the accelerator hypothesis: the relationship between body mass and age at diagnosis of type 1 diabetes.

@article{Kibirige2003TestingTA,
  title={Testing the accelerator hypothesis: the relationship between body mass and age at diagnosis of type 1 diabetes.},
  author={Mohammed S Kibirige and Barbara Metcalf and Remya Rajan Renuka and Terence J. Wilkin},
  journal={Diabetes care},
  year={2003},
  volume={26 10},
  pages={2865-70}
}
OBJECTIVE Previous reports have predicted greater risk of type 1 diabetes among people who were heavier as young children. The Accelerator Hypothesis predicts earlier onset in heavier people, without necessarily a change in risk, and views type 1 and type 2 diabetes as the same disorder of insulin resistance, set against different genetic backgrounds. Insulin resistance is a function of fat mass, and increasing body weight in the industrialized world has been accompanied by earlier presentation… CONTINUE READING

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