Testing the NKT cell hypothesis of human IDDM pathogenesis.

  title={Testing the NKT cell hypothesis of human IDDM pathogenesis.},
  author={Peter T. Lee and Amy Freeman Putnam and Kamel Benlagha and Luc Teyton and Peter A. Gottlieb and Albert Bendelac},
  journal={The Journal of clinical investigation},
  volume={110 6},
Defects in IL-4-producing CD1d-autoreactive NKT cells have been implicated in numerous Th1-mediated autoimmune diseases, including diabetes, multiple sclerosis, rheumatoid arthritis, lupus, and systemic sclerosis. Particular attention has been focused on autoimmune insulin-dependent diabetes mellitus (IDDM) because nonobese diabetic (NOD) mice and humans with IDDM are both reported to express severe deficiencies in the frequency and Th2 functions of NKT cells. Furthermore, experimental… CONTINUE READING


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