Testing statistical significance scores of sequence comparison methods with structure similarity

@article{Hulsen2006TestingSS,
  title={Testing statistical significance scores of sequence comparison methods with structure similarity},
  author={Tim Hulsen and J. de Vlieg and J. Leunissen and P. Groenen},
  journal={BMC Bioinformatics},
  year={2006},
  volume={7},
  pages={444 - 444}
}
BackgroundIn the past years the Smith-Waterman sequence comparison algorithm has gained popularity due to improved implementations and rapidly increasing computing power. However, the quality and sensitivity of a database search is not only determined by the algorithm but also by the statistical significance testing for an alignment. The e-value is the most commonly used statistical validation method for sequence database searching. The CluSTr database and the Protein World database have been… Expand
18 Citations
Normalized global alignment for protein sequences.
  • 4
  • Highly Influenced
Island method for estimating the statistical significance of profile-profile alignment scores
  • A. Poleksic
  • Biology, Computer Science
  • BMC Bioinformatics
  • 2008
  • 8
Algorithms in comparative genomics
Searching for evolutionary distant RNA homologs within genomic sequences using partition function posterior probabilities
  • 11
  • PDF
Algorithms for the study of RNA and protein structure
  • 1
Ranking MEDLINE documents
  • 1
...
1
2
...

References

SHOWING 1-10 OF 29 REFERENCES
Comparative accuracy of methods for protein sequence similarity search
  • 43
  • PDF
Statistical evaluation of pairwise protein sequence comparison with the Bayesian bootstrap
  • 34
  • PDF
Improved tools for biological sequence comparison.
  • W. Pearson, D. Lipman
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1988
  • 10,332
  • PDF
Comparison of methods for searching protein sequence databases
  • W. Pearson
  • Mathematics, Medicine
  • Protein science : a publication of the Protein Society
  • 1995
  • 356
  • PDF
Significance of Z-value Statistics of Smith-Waterman Scores for Protein Alignments
  • 69
  • PDF
Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements.
  • 1,210
  • PDF
Assessing sequence comparison methods with the average precision criterion
  • 27
  • PDF
Fundamentals of massive automatic pairwise alignments of protein sequences: theoretical significance of Z-value statistics
  • 35
  • PDF
Sequence comparisons using multiple sequences detect three times as many remote homologues as pairwise methods.
  • 579
  • PDF
...
1
2
3
...