Testing of the estrogenic activity and toxicity of Stephania venosa herb in ovariectomized rats.

@article{Gomuttapong2012TestingOT,
  title={Testing of the estrogenic activity and toxicity of Stephania venosa herb in ovariectomized rats.},
  author={Sarawoot Gomuttapong and Rangsima Pewphong and Sucha Choeisiri and Sukanya Jaroenporn and S Malaivijitnond},
  journal={Toxicology mechanisms and methods},
  year={2012},
  volume={22 6},
  pages={445-57}
}
Stephania venosa Spreng is a traditional herb which has been used for cancer treatment as well as an aphrodisiac. The scientific literature strongly supports its in vitro antiproliferative effects on cancer cell lines and has suggested developing this plant as a potential anticancer drug. However, the in vivo steroidogenic activity and toxicity of this plant have never been tested. We analyzed the levels of five key isoflavones in the plant extract by quantitative HPLC and then evaluated the in… CONTINUE READING