Testing of sunset yellow and orange II for genotoxicity in different laboratory animal species

  title={Testing of sunset yellow and orange II for genotoxicity in different laboratory animal species},
  author={J. Wever and R. Muenzner and H. Renner},
  journal={Environmental and Molecular Mutagenesis},
The azo dyes Sunset Yellow and Orange II were gavaged to rodent species to check bile, urine, and fecal extracts for possible mutagenic activity in the Ames test or in bone marrow cells for clastogenicity using cytogenetic test systems. After oral application the dyes showed a negative response in bile, excrements, and bone marrow. When an exogenous metabolic activation was performed, increased revertant numbers using Salmonella strain TA100 were obtained only in fecal extracts of Sunset Yellow… Expand
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