Testing human sera for antibodies against avian influenza viruses: horse RBC hemagglutination inhibition vs. microneutralization assays.

@article{Kayali2008TestingHS,
  title={Testing human sera for antibodies against avian influenza viruses: horse RBC hemagglutination inhibition vs. microneutralization assays.},
  author={Ghazi Kayali and Sharon F. Setterquist and Ana W. Capuano and Kendall P. Myers and James S. Gill and Gregory C Gray},
  journal={Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology},
  year={2008},
  volume={43 1},
  pages={73-8}
}
BACKGROUND The hemagglutination inhibition (HI) assay is a frequently used method to screen human sera for antibodies against influenza A viruses. Because HI has relatively poor sensitivity in detecting antibodies against avian influenza A strains, a more complicated microneutralization (MN) assay is often preferred. Recent research suggests that the sensitivity of the HI assay can be improved by switching from the traditionally used turkey, guinea pig, human, or chicken RBCs to horse RBCs… CONTINUE READING

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