Testing for treatment-biomarker interaction based on local partial-likelihood.

Abstract

In clinical trials, patients with different biomarker features may respond differently to the new treatments or drugs. In personalized medicine, it is important to study the interaction between treatment and biomarkers in order to clearly identify patients that benefit from the treatment. With the local partial-likelihood estimation (LPLE) method proposed… (More)
DOI: 10.1002/sim.6563

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