Testing for spatial correlation in nonstationary binary data, with application to aberrant crypt foci in colon carcinogenesis.

@article{Apanasovich2003TestingFS,
  title={Testing for spatial correlation in nonstationary binary data, with application to aberrant crypt foci in colon carcinogenesis.},
  author={Tatiyana V. Apanasovich and Simon Sheather and Joanne R. Lupton and Nata{\vs}a A Popovi{\'c} and Nancy D. Turner and Robert S. Chapkin and Leslie A. Braby and Raymond J. Carroll},
  journal={Biometrics},
  year={2003},
  volume={59 4},
  pages={752-61}
}
In an experiment to understand colon carcinogenesis, all animals were exposed to a carcinogen, with half the animals also being exposed to radiation. Spatially, we measured the existence of what are referred to as aberrant crypt foci (ACF), namely, morphologically changed colonic crypts that are known to be precursors of colon cancer development. The biological question of interest is whether the locations of these ACFs are spatially correlated: if so, this indicates that damage to the colon… CONTINUE READING

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