Testing a covariotide model of DNA substitution.

@article{Huelsenbeck2002TestingAC,
  title={Testing a covariotide model of DNA substitution.},
  author={John P. Huelsenbeck},
  journal={Molecular biology and evolution},
  year={2002},
  volume={19 5},
  pages={698-707}
}
The concomitantly variable codons hypothesis of DNA substitution argues that at any time only a fraction of the codons in a gene are capable of accepting a mutation. However, as mutations are fixed at some positions in a gene, the sites that are potentially variable also change because of changed functional constraints. This hypothesis has been termed the "covarion" hypothesis or when the model is applied to nucleotides, the "covariotide" hypothesis. The covarion-covariotide model has proven to… CONTINUE READING
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