Testing Stem Cell Therapy in a Rat Model of Inflammatory Bowel Disease: Role of Bone Marrow Stem Cells and Stem Cell Factor in Mucosal Regeneration

@inproceedings{Qu2014TestingSC,
  title={Testing Stem Cell Therapy in a Rat Model of Inflammatory Bowel Disease: Role of Bone Marrow Stem Cells and Stem Cell Factor in Mucosal Regeneration},
  author={Bo Qu and Guo-rong Xin and Li-Xia Zhao and Hui Jun Xing and Li-Ying Lian and Hai-yan Jiang and Jia-Zhao Tong and Bei-bei Wang and Shi-Zhu Jin and Michelina Plateroti},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND The gastrointestinal (GI) mucosal cells turnover regularly under physiological conditions, which may be stimulated in various pathological situations including inflammation. Local epithelial stem cells appear to play a major role in such mucosal renewal or pathological regeneration. Less is clear about the involvement of multipotent stem cells from blood in GI repair. We attempted to explore a role of bone marrow mesenchymal stromal cells (BMMSCs) and soluble stem cell factor (SCF… CONTINUE READING
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