Testing SNPs and sets of SNPs for importance in association studies.

@article{Schwender2011TestingSA,
  title={Testing SNPs and sets of SNPs for importance in association studies.},
  author={Holger Schwender and Ingo Ruczinski and Katja Ickstadt},
  journal={Biostatistics},
  year={2011},
  volume={12 1},
  pages={18-32}
}
A major goal of genetic association studies concerned with single nucleotide polymorphisms (SNPs) is the detection of SNPs exhibiting an impact on the risk of developing a disease. Typically, this problem is approached by testing each of the SNPs individually. This, however, can lead to an inaccurate measurement of the influence of the SNPs on the disease risk, in particular, if SNPs only show an effect when interacting with other SNPs, as the multivariate structure of the data is ignored. In… CONTINUE READING