Testing Population-Specific Quantitative Trait Associations for Clinical Outcome Relevance in a Biorepository Linked to Electronic Health Records: LPA and Myocardial Infarction in African Americans

@article{Dumitrescu2016TestingPQ,
  title={Testing Population-Specific Quantitative Trait Associations for Clinical Outcome Relevance in a Biorepository Linked to Electronic Health Records: LPA and Myocardial Infarction in African Americans},
  author={Logan Dumitrescu and Kirsten E. Diggins and Robert J. Goodloe and Dana C. Crawford},
  journal={Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing},
  year={2016},
  volume={21},
  pages={
          96-107
        }
}
Previous candidate gene and genome-wide association studies have identified common genetic variants in LPA associated with the quantitative trait Lp(a), an emerging risk factor for cardiovascular disease. These associations are population-specific and many have not yet been tested for association with the clinical outcome of interest. To fill this gap in knowledge, we accessed the epidemiologic Third National Health and Nutrition Examination Surveys (NHANES III) and BioVU, the Vanderbilt… CONTINUE READING

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