Testing ATRA and MEK inhibitor PD0325901 effectiveness in a nude mouse model for human MPNST xenografts

@inproceedings{FischerHuchzermeyer2018TestingAA,
  title={Testing ATRA and MEK inhibitor PD0325901 effectiveness in a nude mouse model for human MPNST xenografts},
  author={Susan Fischer-Huchzermeyer and Levan Chikobava and Verena Stahn and Monique Zangarini and Philip S. M. Berry and Gareth J Veal and Volker Senner and Victor Felix Mautner and Anja Harder},
  booktitle={BMC Research Notes},
  year={2018}
}
Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas characterized by high recurrence rates and early metastases. These tumors arise more frequently within neurofibromatosis type 1 (NF1) and present with resistance during standard chemotherapy leading to increased mortality and morbidity in those patients. In vitro all-trans retinoic acid (ATRA) and MEK inhibitors (MEKi) were shown to inhibit tumor proliferation, especially when applied in combination. Therefore, we… CONTINUE READING
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