Testin secreted by Sertoli cells is associated with the cell surface, and its expression correlates with the disruption of Sertoli-germ cell junctions but not the inter-Sertoli tight junction.

@article{Grima1998TestinSB,
  title={Testin secreted by Sertoli cells is associated with the cell surface, and its expression correlates with the disruption of Sertoli-germ cell junctions but not the inter-Sertoli tight junction.},
  author={Josephine Grima and Catherine C L Wong and L J Zhu and S D Zong and C. Yan Cheng},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 33},
  pages={21040-53}
}
Testin is a testosterone-responsive Sertoli cell secretory product. In the present study, we demonstrated that the amount of testin secreted by Sertoli cells in vitro was comparable with several other Sertoli cell secretory products. However, virtually no testin was found in the luminal fluid and cytosols of the testis and epididymis when the intercellular junctions were not previously disrupted, suggesting that secreted testin may be reabsorbed by testicular cells in vivo. Studies using… CONTINUE READING

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