Testicular leydig cell hyperplasia as a cause of familial sexual precocity.

  title={Testicular leydig cell hyperplasia as a cause of familial sexual precocity.},
  author={Heinrich K Schedewie and Edward O. Reiter and Inese Z. Beitins and S Seyed and Virgil Wooten and Jorge F Jimenez and E J Aiman and G W Devane and John F Redman and M. Jocelyn Elders},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={52 2},
Testicular Leydig cell hyperplasia was observed in two brothers presenting with progressive sexual precocity at 2 yr of age. Virilization was shown to result from increased secretion rather than decreased clearance of gonadal testosterone. Testosterone hypersecretion appeared to be gonadotropin independent, as basal and gonadotropin-releasing hormone-induced serum LH concentrations were low by both RIA and bioassay. Adrenal steroidogenesis was demonstrated to be normal by ACTH stimulation… CONTINUE READING


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