Testicular hypofunction caused by activating p53 expression induced by reactive oxygen species in varicocele rats

@article{Liang2015TesticularHC,
  title={Testicular hypofunction caused by activating p53 expression induced by reactive oxygen species in varicocele rats},
  author={M. Liang and J. Wen and Q. Dong and L-G Zhao and B. Shi},
  journal={Andrologia},
  year={2015},
  volume={47}
}
We investigated the mechanism of the testicular hypofunction induced by hypoxia in varicocele rats. Varicocele was induced by partial ligation of the left renal vein. Seven weeks later, left testis mass index was measured. The sperm counts and motility were tested by CASA. The change of seminiferous tubule tissue was observed by HE staining. The reactive oxygen species (ROS) level in left testicular tissue was measured by ELISA, and the expressions of HIF‐1α and p53 were detected by… Expand
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