Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23.

  title={Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23.},
  author={Fredrick R Schumacher and Zhaoming Wang and Rolf I. Skotheim and Roelof Koster and Charles Y. C. Chung and Michelle A. T. Hildebrandt and Christian Kratz and Anne Cathrine Bakken and D Timothy Bishop and Michael Blaise Cook and Ralph Loren Erickson and Sophie D Fossa and Mark H Greene and Kevin B. Jacobs and Peter A. Kanetsky and Laurence N. Kolonel and Jennifer T Loud and Larissa A. Korde and Lo{\"i}c Le Marchand and Juan Pablo Lewinger and Ragnhild A. Lothe and Malcolm C. Pike and Nazneen Rahman and Mark V. Rubertone and Stephen M Schwartz and Kimberly D. Siegmund and Eila Curlee Skinner and Clare Turnbull and David J. Van Den Berg and X ianchao Wu and Meredith Yeager and Katherine L Nathanson and Stephen J. Chanock and Victoria K. Cortessis and Katherine A McGlynn},
  journal={Human molecular genetics},
  volume={22 13},
Genome-wide association studies (GWASs) have identified multiple common genetic variants associated with an increased risk of testicular germ cell tumors (TGCTs). A previous GWAS reported a possible TGCT susceptibility locus on chromosome 1q23 in the UCK2 gene, but failed to reach genome-wide significance following replication. We interrogated this region by conducting a meta-analysis of two independent GWASs including a total of 940 TGCT cases and 1559 controls for 122 single-nucleotide… CONTINUE READING
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