Testicular function and fertility in men with Klinefelter syndrome: a review.

@article{Aksglaede2013TesticularFA,
  title={Testicular function and fertility in men with Klinefelter syndrome: a review.},
  author={L Aksglaede and Anders Juul},
  journal={European journal of endocrinology},
  year={2013},
  volume={168 4},
  pages={R67-76}
}
Klinefelter syndrome, 47,XXY (KS), is the most frequent sex chromosome aberration in males, affecting 1 in 660 newborn boys. The syndrome is characterized by testicular destruction with extensive fibrosis and hyalinization of the seminiferous tubules resulting in small testes, hypergonadotropic hypogonadism, and azoospermia in the majority of cases. Until recently, infertility was considered an untreatable condition in KS. However, with the development of new advanced assisted reproductive… CONTINUE READING