Testicular expression of long non–coding RNAs is affected by curative GnRHa treatment of cryptorchidism

  title={Testicular expression of long non–coding RNAs is affected by curative GnRHa treatment of cryptorchidism},
  author={Faruk Had{\vz}iselimovi{\'c} and Gilvydas Verkauskas and Beata Vincel and Michael B. Stadler},
  journal={Basic and Clinical Andrology},
BackgroundCryptorchidism is a frequent endocrinopathy in boys that has been associated with an increased risk of developing testicular cancer and infertility. The condition is curable by combined surgery and hormonal treatment during early pre-pubertal stages using gonadotropin releasing hormone agonist (GnRHa). However, whether the treatment also alters the expression of testicular long non-coding RNAs (lncRNAs) is unknown. To gain insight into the effect of GnRHa on testicular lncRNA levels… 

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The results point to molecular mechanisms that underlie the ability of GnRHa to rescue fertility, and are consistent with the hypothesis that hypogonadotropin-releasing hormone agonist in boys with altered mini-puberty is the consequence of a profoundly altered gene expression program involving protein-coding genes and lncRNAs.

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DMRTC2, PAX7, BRACHYURY/T and TERT Are Implicated in Male Germ Cell Development Following Curative Hormone Treatment for Cryptorchidism-Induced Infertility

RNA-sequencing of testicular biopsies indicates novel testosterone-dependent genes and provides valuable insight into the transcriptional response to both defective mini-puberty and curative GnRHa treatment, which prevents infertility in man with one or both undescended (cryptorchid) testes.

Infertility in Cryptorchidism Is Linked to the Stage of Germ Cell Development at Orchidopexy

The presence of Ad spermatogonia at surgery is an excellent prognostic parameter for future fertility in cryptorchid boys, indicating that boys lacking these cells will develop infertility despite successful orchidopexy at an early age.

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Treatment with LH-RHa was effective in rescuing defective mini-puberty in boys with bilateral cryptorchidism, and all testes completed the transition from gonocytes to Ad spermatogonia.

Successful treatment of unilateral cryptorchid boys risking infertility with LH-RH analogue.

  • F. Hadžiselimović
  • Medicine
    International braz j urol : official journal of the Brazilian Society of Urology
  • 2008
It is demonstrated that infertility in cryptorchidism can be successfully corrected when suitably treated with a LH-RHa, and this innovative hormonal treatment will have a profound effect on the current recommended surgical treatment of boys with undescended testes.

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