Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins.

@article{Nakada2003Testican2A,
  title={Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins.},
  author={Mitsutoshi Nakada and Hisashi Miyamori and Junkoh Yamashita and Hiroshi Sato},
  journal={Cancer research},
  year={2003},
  volume={63 12},
  pages={3364-9}
}
Testican family proteins are putative extracellular heparan/chondroitin sulfate proteoglycans of unknown function. We identified recently N-Tes, which is a product of testican 3 splicing variant gene, as an inhibitor of membrane-type matrix metalloproteinases (MT-MMPs). The inhibitory function is common among testican family members except for testican 2, which was shown to uniquely abolish inhibition of MT1-MMP- or MT3-MMP-mediated pro-MMP-2 activation by other testican family members… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Proteoglycans in the nervous system--the quest for functional roles in vivo.

Matrix biology : journal of the International Society for Matrix Biology • 2001
View 1 Excerpt

Similar Papers

Loading similar papers…