Test of a model of antiarrhythmic drug action. Effects of quinidine and lidocaine on myocardial conduction.

Abstract

The effects of quinidine and lidocaine on the maximum upstroke velocity (Vmax) of the ventricular myocardial action potential were compared with the effects predicted by a model over a wide range of driving rates, rhythm disturbances and holding potentials. These rate-, rhythm- and voltage-dependent effects were accurately predicted by the proposed model… (More)

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Cite this paper

@article{Hondeghem1980TestOA, title={Test of a model of antiarrhythmic drug action. Effects of quinidine and lidocaine on myocardial conduction.}, author={L H Hondeghem and Bertram G. Katzung}, journal={Circulation}, year={1980}, volume={61 6}, pages={1217-24} }