• Corpus ID: 236965980

Test of Significance for High-dimensional Thresholds with Application to Individualized Minimal Clinically Important Difference.

  title={Test of Significance for High-dimensional Thresholds with Application to Individualized Minimal Clinically Important Difference.},
  author={Huijie Feng and Yang Ning and Jiwei Zhao},
  journal={arXiv: Methodology},
This work is motivated by learning the individualized minimal clinically important difference, a vital concept to assess clinical importance in various biomedical studies. We formulate the scientific question into a high-dimensional statistical problem where the parameter of interest lies in an individualized linear threshold. The goal of this paper is to develop a hypothesis testing procedure for the significance of a single element in this high-dimensional parameter as well as for the… 

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