Test of Hardy–Weinberg equilibrium in breast cancer case-control studies: an issue may influence the conclusions

@article{Yu2009TestOH,
  title={Test of Hardy–Weinberg equilibrium in breast cancer case-control studies: an issue may influence the conclusions},
  author={Ke-Da Yu and DI Geng-hong and Lei Fan and Graham A Colditz},
  journal={Breast Cancer Research and Treatment},
  year={2009},
  volume={117},
  pages={675-677}
}
To the Editor, The aim of case-control association studies is to find genetic variants in the human genome that influence common diseases and traits. The Human Genome and HapMap projects have added fresh impetus to this goal by cataloguing the updated genetic data. Although most single-nucleotide polymorphisms (SNPs) must be quasineutral, a proportion of them contribute to disease susceptibility. With regard to breast cancer, it has been widely accepted that common variants within genes… CONTINUE READING
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detection by Hardy–Weinberg test and its quantitative effects on linkage-disequilibrium methods for localizing genes underlying complex traits

  • HW Deng, WM Chen, admixture Recker RR Population
  • Genetics 157:885–897 Breast Cancer Res Treat
  • 2009
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