Test for rare variants by environment interactions in sequencing association studies.

@article{Lin2016TestFR,
  title={Test for rare variants by environment interactions in sequencing association studies.},
  author={Xinyi Lin and Seunggeun Lee and Michael C. Wu and Chaolong Wang and Han Chen and Zilin Li and Xihong Lin},
  journal={Biometrics},
  year={2016},
  volume={72 1},
  pages={
          156-64
        }
}
We consider in this article testing rare variants by environment interactions in sequencing association studies. Current methods for studying the association of rare variants with traits cannot be readily applied for testing for rare variants by environment interactions, as these methods do not effectively control for the main effects of rare variants, leading to unstable results and/or inflated Type 1 error rates. We will first analytically study the bias of the use of conventional burden… CONTINUE READING

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Revised May 2015

Received April
  • Accepted June 2015.
  • 2014

A general framework for detecting disease associations with rare variants in sequencing studies

Lin, D.-Y, Tang, Z.-Z
  • The American Journal of Human Genetics
  • 2011