Test-based exact confidence intervals for the difference of two binomial proportions.

@article{Chan1999TestbasedEC,
  title={Test-based exact confidence intervals for the difference of two binomial proportions.},
  author={Ivan Siu Fung Chan and Zhengjun Zhang},
  journal={Biometrics},
  year={1999},
  volume={55 4},
  pages={1202-9}
}
Confidence intervals are often provided to estimate a treatment difference. When the sample size is small, as is typical in early phases of clinical trials, confidence intervals based on large sample approximations may not be reliable. In this report, we propose test-based methods of constructing exact confidence intervals for the difference in two binomial proportions. These exact confidence intervals are obtained from the unconditional distribution of two binomial responses, and they… CONTINUE READING